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For instance, nsPEF exert tumor-ablation effects primarily through subcellular membrane electroporation, offering cell-type specificity with minimal thermal damage while synergizing with chemotherapeuticspositioning it as a promising modality for melanoma treatment ( in vitro ( 3.5 Gliomas For gliomas, PEFs (specifically IRE and nsPEF) effectively address the limitation of traditional chemotherapeutic agents being unable to penetrate the blood-brain barrier (BBB), enabling targeted treatment of tumor lesions while minimizing collateral damage to healthy brain cells ( in vitro biological endpoints and transcriptomic and bioinformatic analyses, that PEFs affects cell proliferation, differentially regulates hypoxia, inflammation, and p53/cell cycle checkpoints, significantly reduces the capacity to form new neurospheres, inhibits invasive potential, and alters the expression of stemness/differentiation genes ( 3.6 Breast cancer PEFs effectively overcome chemoresistance in breast cancer while offering a minimally invasive, safe, and efficacious therapeutic approach

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Unlike the fat you can see or pinch, visceral fat is metabolically active, fueling inflammation, hormonal imbalances, and chronic diseases