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The compounds safety and pharmacological profile have been comprehensively assessed in rodent models.In preclinical trials, including those involving ovariectomized (OVX) rat models, both low- and high-dose AOD-9604 regimens showed no significant toxicity

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In this situation, it can be challenging to demonstrate B12 deficiency even when there are typical symptoms (including neuropathy-like paraesthesia and numbness), as serum B12 concentrations may be just within, or sometimes above, the normal range due to the oral supplementation