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Practically, the PCOS-specific trials measuring this fasting insulin, HOMA-IR scores, postprandial glucose responses, before and after NAC supplementation are smaller and more variable than the trial body behind inositol, vitamin D, or metformin

This results from a tyramine-induced depletion of norepinephrine normally present in the readily releasable vesicle pool, and replacement of vesicular norepinephrine with tyramine (which functions as a false- or pseudo- neurotransmitter), which when released has no effect on postsynaptic adrenergic receptors (Figure 1)

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However, when the delicate balance of microbes in the gut is disrupted, it can lead to a condition known as gut dysbiosis