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1 Introduction Glucagon-like peptide-1 (GLP-1), a hormone derived from the intestine, is released after eating and stimulates insulin secretion from the pancreas in a glucose-dependent manner ( With the alarming increase in the prevalence of type 2 diabetes (T2D) and its associated complications, the need for effective therapeutic strategies have become increasingly urgent ( Studies have shown gastrointestinal disturbances as the most common adverse drug reactions (ADR) associated with semaglutide

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Sweating is not listed in the Summary of Product Characteristics or MHRA prescribing information as a recognised adverse effect

However, safety and efficacy of metformin extended-release tablets in the pediatric population have not been established