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The concern is physiological and behavioral rather than a classic drug-drug interaction

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The existence of this correlation is supported by preclinical studies in mouse xenograft models, which showed that the therapeutic inhibition of angiogenesis reduces tumor vascularization and causes hypoxia, and therefore may promote c-Met-mediated invasion of malignant cells [50]

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Employers and their pharmacy benefit managers (PBMs) can now address obesity as part of a comprehensive cardiometabolic strategyat a fraction of traditional costs

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