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Nutraceuticals tailored modulation of these pathways, which are frequently dysregulated in chronic illnesses, provides a multifaceted treatment strategy with low toxicity

Disruption of the normal gut microbiota may lead to intestinal dysbiosis, barrier dysfunction, bacterial translocation, and excessive production of uremic toxins, including indoxyl sulfate (IS), p-cresyl sulfate (p-CS), and trimethylamine-N-oxide (TMAO), all of which are implicated in the variant processes of kidney diseases development (Chen et al., 2019)

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