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-fucosidase (AFU) is widely present in various tissues and cells, as a member of the glycosidase family, AFU can hydrolyze -L-focusidase residues on lysosomes and their terminal glycolipids or glycoproteins.It is highly active within a pH range of 46.5

It is injected by veterinarian or trained dog owner in the form of cyanocobalamin or hydroxocobalamin

Furthermore, despite several studies providing interesting data, this association should be interpreted with caution because the majority of these studies did not report or adjusted for the effect of ITB in their survival analyses [24]

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