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The major complications of chronic bronchitis include: Difficulty breathing, sometimes severe Respiratory failure Pneumonia Enlargement and weakness of the right heart ventricle of the heart caused by lung disease Pneumothorax (collection of air or gas in the lung causing lung collapse) Polycythemia (abnormally high concentration of red blood cells needed to carry oxygen) Chronic obstructive pulmonary disease (some NIH researchers consider chronic bronchitis a type of COPD) Emphysema Chronic advancement of the disease High mortality (death) rate (COPD is the fourth leading cause of death in the United States) Is it possible to prevent chronic bronchitis