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The study was conducted by Dr Marcel Muskiet of Leiden University Medical Center in the Netherlands, Professor David Cherney of the University Health Network and the University of Toronto in Canada and colleagues

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Consistent with our previous findings (20), oral gavage of systemically active doses of sitagliptin (10 mg/kg) inhibited plasma DPP-4 activity by approximately 85% when assessed 30 minutes after oral administration (Figure 1B)