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Data availability The authors declare that the data supporting the findings of this study are available within the paper and its supplementary information files

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doi: 10.15252/embr.202256614 Summary Keywords mitochondria, infection, mitochondrial dynamics, pathogens, host defense Citation Yang Y, Zeng Y, Liu Z and Huang J (2025) Pathogen-induced mitochondrial dysfunction: mechanistic insights, immune crosstalk, and therapeutic opportunities