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2.3 Amino acid metabolism and antioxidant systems regulate ferroptosis Abnormal amino acid metabolism leads to the inactivation of antioxidant systems, and the accumulation of lipid peroxidation products is regulated by antioxidant systems, which are considered critical determinants of whether ferroptosis occurs

earlier theories that black cohosh acts as a phytoestrogen have been largely refuted, with more recent work pointing to serotonergic activity [21]

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